It is a pleasure to welcome you to the internet page of the FORM-lab, which stands for Frankfurt Orofacial Regenerative Medicine. The origin of the FORM-lab was laid at the Institute of Pathology the Johannes Gutenberg University (JGU) in Mainz where the founders established the in vivo research to analyze the tissue reactions to biomaterials. Three years ago the former in vivo research group established a new lab at the Goethe University in Frankfurt am Main under the patronage of Prof. Dr. Robert Sader, the head physician of the Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery.
The principal aim of the FORM-lab is to use life science approaches to study cell and tissue interaction with biomaterials. Most of the methodology concerns the culture of human cells, with subsequent structural and functional characterization of their interactions with biomaterials for Tissue Engineering (TE) & Regenerative Medicine (RegMed). Many of the techniques involve the study of cellular cross-talk in 3D co-cultures on biomaterial scaffolds or in hydrogel matrices. Thus, one mainstay of the REPAIR-lab is the in vitro research group. However, there are two additional mainstays, both of which are essential for clinical translation. These are the in vivo and the clinical research groups. The in vivo group uses different animal models to study the tissue interactions with different biomaterial classes. The focus of this research is on the classification of the inflammatory response to biomaterials and an implant bed vascularization. The clinical research group analyzes the clinical outcome of different regenerative strategies including different biomaterial classes.
The laboratory has a constant flow of national and international students in medicine, dentistry and biology, who are doing master or doctorate theses. In addition, post-doctoral scientists, visiting professors and laboratory technicians from various nations have visited the laboratory to learn new techniques and conduct collaborative work. Thus, we are always interested in new research and new collaboratories.
We hope you will enjoy your visit to the site, and thank you for taking an interest in our research activity.
Shahram Ghanaati, MD, DMD, PhD
Associate Professor & Executive Senior Physician
Chairman of the FORM-lab